Defective Phagocytosis in Anaplasma phagocytophilum - Infected Neutrophils
نویسندگان
چکیده
منابع مشابه
Anaplasma phagocytophilum–infected Ticks, Japan
We report Anaplasma phagocytophilum infection of Ixodes persulcatus and I. ovatus ticks in Japan. Unique p44/msp2 paralogs (and/or 16S rRNA genes) were detected in tick tissues, salivary glands, and spleens of experimentally infected mice. These findings indicate the public health threat of anaplasmosis in Japan.
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Anaplasma phagocytophilum, an unusual obligate intracellular pathogen that persists within neutrophils, causes human anaplasmosis (previously known as human granulocytic ehrlichiosis). To study the effects of this pathogen on the transcriptional profile of its host cell, we performed a comprehensive DNA microarray analysis of the early (4-h) transcriptional response of human neutrophils to A. p...
متن کاملIntrauterine Transmission of Anaplasma phagocytophilum in Persistently Infected Lambs
Anaplasma phagocytophilum, which causes the disease tick-borne fever (TBF), is the most important tick-borne pathogen in European animals. TBF may contribute to severe welfare challenges and economic losses in the Norwegian sheep industry. The bacterium causes a persistent infection in sheep and several other animal species. The objective of this study was to investigate whether intrauterine tr...
متن کاملTransformation of Anaplasma phagocytophilum
BACKGROUND Tick-borne pathogens cause emerging zoonoses, and include fastidious organisms such as Anaplasma phagocytophilum. Because of their obligate intracellular nature, methods for mutagenesis and transformation have not been available. RESULTS To facilitate genetic manipulation, we transformed A. phagocytophilum (Ap) to express a green fluorescent protein (GFP) with the Himar1 transposas...
متن کاملAnaplasma phagocytophilum, Sardinia, Italy
1. McQuiston JH, Childs JE. Q fever in humans and animals in the United States. Vector Borne Zoonotic Dis. 2002;2: 179–91. 2. Maurin M, Raoult D. Q fever. Clin Microbiol Rev. 1999;12:518–53. 3. Stoker MGP, Marmion BP. The spread of Q fever from animals to man: the natural history of a rickettsial disease. Bull World Health Organ. 1955;13:781–806. 4. Spicer AJ. Military significance of Q fever: ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2005
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.73.2.1187-1190.2005